![]() The overall three-dimensional shape of a protein molecule is the tertiary structure. The anti-parallel ß-sheet is more stable due to the more well-aligned hydrogen bonds. The two strands can be either parallel or anti-parallel depending on whether the strand directions (N-terminus to C-terminus) are the same or opposite. The carbonyl oxygens in one strand bonds with the amino hydrogens of the adjacent strand. The sheet conformation consists of pairs of strands lying side-by-side. The hydrogen bonding in a ß-sheet is between strands (inter-strand) rather than within strands (intra-strand). ![]() The side-chain substituents of the amino acids fit in beside the N-H groups. The hydrogen bonds make this structure especially stable. Hydrogen bonds form between the oxygen of each C=O bond in the strand and the hydrogen of each N-H group four amino acids below it in the helix. ![]() The side-chain substituents of the amino acid groups in an α-helix extend to the outside. The α-helix is a right-handed coiled strand. The two main types of secondary structure are the α-helix and the ß-sheet. Stretches or strands of proteins or peptides have distinct, characteristic local structural conformations, or secondary structure, dependent on hydrogen bonding. While the amino acid sequence makes up the primary structure of the protein, the chemical/biological properties of the protein are very much dependent on the three-dimensional or tertiary structure. Often, post-translational modifications, such as glycosylation or phosphorylation, occur which are necessary for the biological function of the protein. Proteins are synthesized by a series of steps called transcription (the use of a DNA strand to make a complimentary messenger RNA strand – mRNA) and translation (the mRNA sequence is used as a template to guide the synthesis of the chain of amino acids which make up the protein). The amino acid sequence of a protein is encoded in DNA. The remaining 10 are called essential amino acids and must be obtained in the diet. Although 20 amino acids are required for synthesis of various proteins found in humans, we can synthesize only ten. These abbreviations are commonly used to simplify the written sequence of a peptide or protein.ĭepending on the side-chain substituent, an amino acid can be classified as being acidic, basic or neutral. Each amino acid has both a one-letter and three-letter abbreviation. The structures of the 20 amino acids commonly found in proteins are shown in Figure 1. These side chains confer different chemical, physical, and structural properties to the final peptide or protein. The amino acids differ in structure by the substituent on their side chains. The terms, amino-terminus and N-terminus, describe the end of the sequence with a free α-amino group. The end of the peptide or protein sequence with a free carboxyl group is called the carboxy-terminus or C-terminus. A protein can be made up of one or more polypeptide molecules. Sequences with fewer than 50 amino acids are generally referred to as peptides, while the terms, protein and polypeptide, are used for longer sequences. This difunctionality allows the individual amino acids to join in long chains by forming peptide bonds : amide bonds between the -NH 2 of one amino acid and the -COOH of another. Amino acids, as their name indicates, contain both a basic amino group and an acidic carboxyl group. ![]() There are 20 different standard L-α-amino acids used by cells for protein construction. Proteins are macromolecules and have four different levels of structure – primary, secondary, tertiary and quaternary. The term, structure, when used in relation to proteins, takes on a much more complex meaning than it does for small molecules. It will also cover briefly how protein structure can be affected during formulation and some of the analytical methods which can be used both to determine the structure and analyze the stability of the protein. This technical brief aims to give the reader a quick overview of protein structure. Formulation of a protein drug product can be quite a challenge, and without a good understanding of the nature of protein structure and the conformational characteristics of the specific protein being formulated, the results can be ruinous. Increasingly, drug developers are looking to large molecules, particularly proteins, as a therapeutic option. Implantable Drug Delivery Systems and Combination Products Dosage Forms.Solubility & Bioavailability Enhancement. ![]()
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![]() ![]() You may also use OneDrive on Autodesk AutoCAD and rest assured your work is properly backed up. Sync photos across all devices using the Microsoft Photos App. It's integrated into Windows 10 so you no longer need to download any application. OneDrive is Microsoft's answer to your storage needs. Get up to 15GB worth of storage for no cost while their paid plans provide you top-notch service for a low price. View photos and play videos easily or connect it with Pixlr Editor to quickly retouch a few images. You may use it in conjunction with other products from the tech giant like Google Docs, Google Sheets, and Google Slides. It's perfect for cloud collaboration and file sharing. Unlike that of Apple's Google offers their services to users of all devices. Google Drive is one of the easiest and most reliable storage solutions. If you think iCloud isn't for you, there are a lot of cloud-storage service providers to choose from. If you don't want to set up the desktop client, you may also access your files by logging in through the web app. It works in the background just as it does on other devices. However, Windows users who own mobile Apple devices need to download their Windows-friendly version. This means that there is no need for you to download the application on your iPhone, iPad, MacBook, Mac or Apple TV. Like all Apple programs, iCloud is integrated on all Apple devices. That being said, if you are really looking for a cloud storage service app that allows you to not only keep your files across devices sync and collaborate with other people, you need to consider other options. The same goes for the web because it will ask you to input your AppleID instead of an iCloudID. Yes, even if you're willing to pay for the service. If all these weren't disappointing enough, you can't just activate iCloud on your PC if you haven't registered and used it on your iOS or macOS device. Needless to say, you can't just drag and drop files just as easily as you can on the Mac and iOS clients. Sadly, both leading tech companies are yet to come up with a mechanism to convert these files into an editable format. The platform also can't identify other file types including Microsoft Office documents. While the former already has sections for applications like iCalendar you won't find it on the later version. If you're accustomed to the slick interface iCloud has for Mac and iOS, you might need to adjust a little on its Windows client. You can easily share any file straight from File Explorer and collaborate with others. Need to access your files on someone else's laptop? Log in to your iCloud account via the web app and easily download that report you worked hard on last night. on the drive and access them on your iOS or Mac by syncing them together. You may also store your photos, documents, videos, etc. ![]() Select which file or folder you want to keep on your computer and which ones you want to be stored in the cloud. Free up some space on your computer and access your iCloud Drive files right from File Explorer. Using the same technology as that of OneDrive, iCloud Windows users can be more productive even if they aren't connected to the internet. The program is available only to Windows 10 version so you have to make sure that your operating system is up to date before you can use the application on your PC. This time around, Apple decided to work with Microsoft to streamline iCloud's performance for Windows. While this should generally be considered as good news, but don't celebrate just yet until you try it for yourself. ![]() Apple phone and tablet users who are on laptop and PC can now sync their files across all their devices using the built-in application from Apple. It wasn't a long time ago when Microsoft announced that the iCloud will have a Windows-friendly version available on the Microsoft Store. If you're accustomed to the slick interface iCloud has for Mac and iOS, you might need to adjust a little on its Windows client Best cloud storage solution for Apple devices but not for Windows ![]() ![]() The power wire is typically red, and should be connected to the 5V pin on the Arduino board. Servo motors have three wires: power, ground, and signal. On the Mega, up to 12 servos can be used without interfering with PWM functionality use of 12 to 23 motors will disable PWM on pins 11 and 12. On boards other than the Mega, use of the library disables analogWrite() (PWM) functionality on pins 9 and 10, whether or not there is a Servo on those pins. The Servo library supports up to 12 motors on most Arduino boards and 48 on the Arduino Mega. Continuous rotation servos allow the rotation of the shaft to be set to various speeds. Standard servos allow the shaft to be positioned at various angles, usually between 0 and 180 degrees. Servos have integrated gears and a shaft that can be precisely controlled. This library allows an Arduino board to control RC (hobby) servo motors. If this happens, then you can usually cure it by adding a high value capacitor (470uF or greater) between GND and 5V on the breadboard. This is because the servo draws quite a lot of power, especially as the motor is starting up, and this sudden high demand can be enough to drop the voltage on the Arduino board, so that it resets itself. Our servo may behave erratically, and you may find that this only happens when the Arduino is plugged into certain USB ports. The graphic makes it a little easier to understand. In between, it represents the value from 0–180. At 1 millisecond it represents 0 degrees and at 2 milliseconds it represents 180 degrees. At the beginning of each cycle, the signal is HIGH for a time between 1 and 2 milliseconds. Each cycle in the signal lasts for 20 milliseconds and for most of the time, the value is LOW. But what kind of signal do they receive on the input pin? Internally, they have a motor driver and a feedback circuit that makes sure that the servo arm reaches the desired position. Using just one input pin, they receive the position from the Arduino and they go there. This control lead is connected to digital pin 9. ![]() The other lead is the control lead and this is usually orange or yellow. The color of the leads varies between servo motors, but the red lead is always 5V and GND will either be black or brown. Servo consists of shell, circuit board, non-core motor, gear and location detection.The servo motor has three leads. ![]()
![]() Forecast Valid: 2am EDT Jul 13, 2023-6pm EDT. Local Graphical Aviation Marine Rivers and Lakes Hurricanes Severe Weather Fire Weather. Calendar overview of Months Weather Forecast. NOAA National Weather Service National Weather Service. See a list of your local health and activity forecasts and recommendations. Free Long Range Weather Forecast for Aldie, Virginia. My go to is the BBQ ribs, which says something as I didn't think anyone made ribs as good as I do! You can get half or whole racks with hot or mild sauce, and although the sauce is good, it isn't the star,the ribs themselves are! Make sure you grab lots of napkins, because you're going to need them! No need to feel self conscious, everyone else around you will be doing the same! Whether you sit down at the picnic table there, sit on your tailgate and enjoy, or take them home, you are in for a great BBQ experience when you stop by RJ's Pit Stop! Some Thoughts!: 1) They do take Credit Card 2) Listen to others as they order, you may have time since there's usually a line, so you'll know what and how to order when its your turn! Don't want to look like a rookie! 3) Get their early! By 12 there's usually a long line, and since everything is taken off the pits and prepared for you when you order, you might have a little bit of a wait. Weather conditions can be closely tied with health-related pains and outdoor activities. (✯) Humidity () Wind (mph) Pressure (in) Washington/Dulles International Airport, DC. Forecast Valid: 5am EDT Jun 7, 2023-6pm EDT. RJ's Pit Stop is making BBQ the right way, and it shows! On any given Saturday and Sunday you can find a long line of regulars intertwined with newcomers waiting to get their hands on some of the best BBQ anywhere! Although there isn't a huge selection, what they do make is done right! Whether your prefer the BBQ Chicken, BBQ Ribs, Pulled Pork, Rib Tips (After 2 or 2:30pm), or their delicious chicken spread, you can bet its delicious! After picking out your main dish, make sure to save room for a side of potato salad or my favorite side, kale! You heard me right, kale! Cooked with ham, the kale will win over even the staunchest of carnivores. Aldie VA: Enter Your 'City, ST' Location Time (est) Sky/Weather Temp. NOAA National Weather Service National Weather Service. If convicted of all charges, Newman could face up to 16 years in prison, based on Virginias sentencing guidelines. ![]() Positioned in Loudon County where RT50 meets RT15 at a traffic circle known as Gilberts Corner is a gentleman who has figured out what it seems like so many others have missed or forgotten! Not far from the hustle and bustle of Fairfax County, and the myriad of fast, cookie cutter chain restaurants is RJ's Pit Stop. 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Please check with your country's customs office to determine what these additional costs will be prior to bidding or buying. These charges are the buyer's responsibility. Please Note: 1: Import duties, taxes, and charges are not included in the item price or shipping cost. But please contact with our customer service first before returning or opening a refund, we will try our best to help you. Return Money Back guarantee within 30 days if returned by customer. We have never missed the shipping deadline set by eBay, so please wait until it ships. Please refrain from inquiring about the shipping date of your package, as it will put pressure on our packing staff and it will take even longer to ship your package. *We are currently packing with a small staff to prevent infection. *We can check to see if you are in a remote control area, so please contact us with your address before you make your purchase. *The additional shipping charge is US$10 - 30. *DHL and FedEx charge an additional shipping fee, called a remote delivery fee, depending on the destination area. *Expedited Shipping - Shipped by DHL or FedEx. It may take more than 10 days to arrive depending on the number of airfreight. *Standard Shipping - Shipped by Japan Post. ![]() ![]() Shipping If we can pack it with other items, we can give you a discount, so please let us know. Our professional staff will be happy to answer any questions you may have. Description Please feel free to contact us for product descriptions or more information. Please feel free to contact us for product descriptions or more information.Our professional staff will be happy to answer any questions you may have. Item: 133845908565 RARE Final Fantasy XIV FFXIV Wind-up Nu Mou Plush doll Exclusive to JAPAN TAITO. ![]() ![]() ![]() You start in a small room with no idea what lies beyond its doors and must make your way to your objectives, in whatever fashion you see fit.ĭue to the extreme amount of customisation in the game it’s quite difficult to discuss the actual gameplay in Invisible, Inc. Room layout and configuration, guards, hazards, everything is entirely new each time you enter a level. is procedurally generated, meaning that no matter how many times you play the game you’ll never encounter the same level twice. Once you’ selected a target you’re beamed into a procedurally generated level. ![]() You might decide to raid a corporate vault for some much needed credits, head to a detention centre to rescue a captured agent (and unlock the agent for use in future campaigns, as well as the current on), or go hunting for various weapons or upgrades for your agents. There are a wide variety of different types of missions available for you to select, each with their own objectives. The narrative will have you believe that you’re trying to find a home for your AI, who has 72 hours of emergency power left before shutting down completely. will see you jetting around the world, infiltrating various corporate facilities for various reasons. You can tailor the game to suit your style of play here too. Once again, something as simple as selecting your starting characters is done really well and has a big impact on your experience. It goes without saying that each agent comes with their own perks and special abilities, and which agents are best for you is going to be dictated by your play style. ![]() Once you’ve toyed around with the difficulty screen for as much time as you would a character creator in an RPG (or is that just me?), you’ll be given the option to select two agents from a pool of unlockable characters to form your agency, and the game will send you on your way. It’s frankly amazing, and how I want all games to approach game difficulty from now on. If there’s something about the gameplay you don’t like, you can probably turn it off in the difficulty options menu next time you restart. You’re in complete control of your experience in Invisible, Inc. I know I’m going on and on about a single menu in the game, and I’ll get to all the other good stuff in a moment, but it’s worth pontificating over because it’s absolutely bloody brilliant. Namely to craft an incredibly rich, deep and accessible tactical experience for anyone who plays the game. It’s also your first taste of what I believe Keli Entertainment were aiming for when they were developing Invisible, Inc. You can choose how big or small levels will be, how many guards will appear, how plentiful your starting resources will be, the difficulty of guard patrols, the number of safes, terminals… gives it’s players complete control over their gameplay experience from the word go, and it’s absolutely brilliant. Hidden just behind the custom difficulty tab are a mind-boggling twenty-three options for doing so. When you generate a new campaign and you’re selecting the difficulty you want to play at, you’re given the option to customise your experience by customising the difficulty. It’s the bottom option of these advanced difficulties where things get really interesting. There are three standard difficulties, beginner, experienced, and expert, and there are also five advanced difficulties. After a brief tutorial and an awesome, cartoon animated cutscene sets up the games story, you’re dropped at the difficulty selection. It starts from almost the very first screen that allows you to select and customise your difficulty. Klei Entertainment have crafted an incredibly deep game, and it’s a depth that permeates every part of the experience in Invisible, Inc. If there’s one word that can be used to describe Invisible, Inc. After your corporation is attacked you’re forced on the run, desperately infiltrating rival corporations as you attempt to survive and find a foothold in the world. In the game you take on the role of The Operator, essentially the person in command of Invisible’s agents when they’re out in the field. is an isometric, grid-based strategy game in a similar vein to 2012’s fantastic XCOM: Enemy Unknown, albeit with more of a focus on stealth, cyberpunk and making a ton of cash as opposed to fighting a desperate war against an overwhelming alien onslaught. ![]() ![]() ![]() ![]() ![]() You can calculate the historic volatility, MACD, RSI and many other technical indicators. Our interactive charts include live gold and silver prices, along with live prices for the wide variety of products Monex has to offer. You can now plot and analyze this data using all of Excel’s tools. Live Gold and Silver Prices Historical Price Charts Current Live Prices Track the value and performance of precious metals changes in real time and in one convenient location. Just pick the currency from the drop-down menu.Ī complete list of currencies (together with their ISO 4217 currency code) is given on the right-hand side of the Parameters sheet (don’t delete this list – it’s used to populate the currency drop-down menu). These include historic gold and silver prices in USD, GBP, CAD, CNY, JPY and many more. Your price data is returned in one of 164 currencies. Real-time and historical prices: Detailed real-time, delayed and historical pricing from all the major commodities exchanges around the world. Jaguar reports gold production decline in Q2, suspends. We enable you to identify profitable gold (over 350 projects and mines) and copper (over 26 largest copper producing companies) and analyse which mines and projects offer the best growth opportunities. (Kitco News) - Lithium supply must ramp up to keep momentum building in the sector, said Chris Doornbos, Founder and CEO of E3 Lithium. This process is fully automated and takes place behind-the-scenes with some clever VBA. Dont give the market an excuse to move off lithium. The spreadsheet then connects to a web-service that provides historic prices for gold and silver, and downloads daily closing prices between the two dates. and finish by clicking on the “Get Data” button.then select the currency you want prices in,.choosing whether you want historic prices for either gold or silver,.That’s where this spreadsheet comes into play – it gives you quick access to historic price data across many different currencies. These two precious metals form a significant part of many portfolios, and clever investors need to keep tabs on historic prices. The price of gold remained remarkably stable for long periods. Gold and silver have been on a roll-coaster over the last few years. Taken from Timothy Greens Historical Gold Price Table, London prices converted to U.S. You can get prices in many different currencies. When you return to the cookie will be retrieved from your machine and the values placed into the calculator.Get historical prices for gold and silver with this free web-connected spreadsheet. Pressing the button will place a cookie on your machine containing the information you entered into the Holdings Calculator. If your browser is configured to accept Cookies you will see a button at the bottom of the Holdings Calculator. The spot price of Gold per Troy Ounce and the date and time of the price is shown below the calculator. Totals for Gold and Silver holdings including the ratio percent of gold versus silver will be calculated. The Current and Future Gain/Loss will be calculated. Optionally enter number amounts for Purchase Price and/or Future Value per unit of weight chosen. The DoubleLine Capital CEO turned bullish on gold after it crossed the 1,800 an ounce level, and he believes 'its a reasonably good time to buy gold and own gold. Theyre going to make it just under 5 by May or June and then start cutting,' he said. The Current Value for the amount entered is shown. 'The bond market pricing shows that the Fed is not going to make it to 5. The current price per unit of weight and currency will be displayed on the right. If you wish to select a currency other than USD for the Silver holdings calculator. NOTE: You must select a currency for gold first, even if you don't enter a value for gold holdings. Select Ounce, Gram or Kilogram for the weight. The Holdings Calculator permits you to calculate the current value of your gold and silver.Įnter a number Amount in the left text field. ![]() ![]() ![]() To Understand How COVID-19/ Russia-Ukraine War Influence Click The Link. We provide personalized solutions designed to the specific requirements of company, utilizing the market data available. Who are the top key players in this market?.Which region has highest growth rate in Learning Management System (LMS) Market?.What is Learning Management System (LMS) Market size in 2028?.What is the growth rate of Learning Management System (LMS) Market?.What is the study period of this market?.Must-have information for market players to sustain and enhance their market footprint A neutral perspective on market performance Potential and niche segments, geographical regions exhibiting promising growth Strategies of key players and products offered Recent industry trends and developments Historical, current and projected market size in terms of volume and value Changing market dynamics in the industry Key Highlights Covered in this Updated Research Reports Include: Inquire or Share Your Questions If Any Before the Purchasing This Report. Additionally, the market is expanding due to the increasing awareness of IOT technology in countries such as India and China, in the Asia-Pacific region. Among various regions, North America is expected to be the most profitable region globally. The growth of the Learning Management System (LMS) market can be attributed to the widespread adoption of Industry. Middle East and Africa (Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA)).Asia-Pacific (China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC)).Europe (Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe).South America (Brazil, Argentina and Rest of South America).North America (U.S., Canada and Mexico). ![]() The worldwide Learning Management System (LMS) market has been categorized based on geography as follows: Most widely used downstream fields of Learning Management System (LMS) market covered in this report are: Most important types of Learning Management System (LMS) products covered in this report are: Global Learning Management System (LMS) Market: Segmentation Get Sample Copy of Learning Management System (LMS) Market Report Moreover, the report covers topics such as mergers and acquisitions, emerging market trends, the impact of COVID-19, and regional conflicts, to provide a holistic picture of the market landscape. ![]() It provides detailed profiles of the leading companies, enabling readers to gain a better understanding of their competitors and the competitive scenario. The report on the Learning Management System (LMS) market presents a comprehensive competitive landscape analysis, showcasing the industry players' market share, concentration index, and other pertinent metrics. Some of the Prominent Market Players are: The report has been crafted through a rigorous analysis of primary and secondary research methodologies to extract valuable insights from various companies in a unique manner. The market report on the Learning Management System (LMS) industry presents a summary of the market dynamics, including the evolving customer needs in different regions. This comprehensive research report is titled ‘Learning Management System (LMS) Market’ with Industry Analysis and Opportunity Assessment and it comprises a whole market scenario along with the dynamics affecting it. “ Learning Management System (LMS) Market” research report provides an authentic industry viewpoint, future trends and dynamics for market growth rate, market size, trading and key players of the industry with forecast period of 2023 to 2030. ![]() ![]() ![]() Google's Pixel phones are all about the "pure Google" experience, and part of that means you don't get all the superfluous gunk and overlapping services manufacturers and carriers love to bake into Android phones. If you buy the Pixel from Verizon, your phone will come with some bloatware. So that's another possibility to consider - though it appears buying the Pixel from Best Buy is equivalent to buying it from Verizon, which is a relevant distinction to keep in mind for the next few items. (You can compare the specifics for yourself if you want here's Verizon's protection plan page and Google's protection plan page.)Īnd at the risk of complicating things further, I should also point out that Best Buy is running a promotion right now where if you buy a Pixel phone there and activate it on Verizon, the store will give you a $100 Best Buy gift card and a free 2015 Chromecast. (On the other hand, of course, you could always sell your old phone independently and probably get close to that same amount.)īoth Verizon and Google offer device protection plans, meanwhile - though according to the details posted on each company's website, Verizon's offering appears to be significantly more expensive. Verizon says it'll go as high as $300, depending on the device and condition. If you buy the phone from Verizon, however, you'll have the option to trade in your old phone and get credit toward your new purchase. And both Google and Verizon are currently offering free Daydream View VR headsets along with all pre-orders. if you want to go the financing route (which both Google and Verizon provide as an option). The basic pricing is the same either way you go: $650 outright for the base Pixel model or $27/mo. The hardware itself may be the same, but the experience of buying the Pixel from Google and buying it from Verizon is not identical. There are some differences between buying the Pixel from Google and buying it from Verizon. Pixels sold through Verizon are even unlocked - so if you buy the phone from the carrier and decide you want to switch to another provider at some point down the line, you should have no problem swapping out the SIM and moseying onward. Either way will work fine, as I confirmed directly with Verizon ("Folks are welcome to purchase unlocked through Google or through Verizon both models will connect to our network," a spokesperson told me). So, yes, you can buy the Pixel from Verizon if you want - or you can buy it unlocked from Google, then put a Verizon SIM into it and use it on Verizon's network. And it's going to be compatible on virtually any network, including Verizon's, regardless of where you get it. Whether you buy a Pixel from Verizon or from Google, you're getting the same physical device. This isn't 2012, where Google sold one version of its flagship phone and Verizon sold another. Even if you want to use Verizon, you don't have to buy the Pixel from Verizon. Verizon is simply the only carrier that's selling the phone directly - on its own website and in its own stores. You can buy it unlocked, directly from Google, and use it on practically any carrier. We can quibble all day over semantics, but here's the real deal: The Pixel phone is not a Verizon exclusive. And it’s only on America's largest and fastest 4G LTE network. I've seen lots of language - in marketing materials, promotional tweets, and ads all over mainstream news sites - touting the Pixel as being "only on Verizon" or "exclusively available" on Verizon. The Pixel isn't really a Verizon "exclusive." (And be sure to read all the way through this, because the last point may be the most important one of all.) 1. ![]() So let's take a minute to clear things up, shall we? Yup - there's a lot of incomplete and misleading info out there about what exactly is going on with Google's Pixel phones and Verizon here in the U.S. But hold the phone: Staying in line with the companies' complicated history, this new arrangement isn't quite what it seems. Now here we are, seven years after that first Droid, and Verizon is teaming up with Google once again - this time as the "exclusive" carrier partner for Google's new flagship Pixel phones. ![]() |
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